From SF Bay Area:
Take I-580 eastbound over Altamont Pass to I-205 toward Stockton, to US 99 North. Take the exit for State Hwy 4 Eastbound (Angel's Camp) to the Park Entrance. Hwy 4 makes a jog to the right in Angel's Camp along State Hwy 49, then jogs left just before leaving town. Calaveras Big Trees is about 35 minutes driving from Angel's Camp.
From Southern California:
Take either I-5 or US 99 North. From I-5 you can cross to the other side of Stockton on State Hwy 4 to 99/4 South a few miles, then follow Hwy 4 towards and beyond Farmington to the Park. Hwy 4 makes a jog right in Angel's Camp, then jogs left just before leaving town. Calaveras Big Trees is about 35 minutes driving time from Angel's Camp.
Take US 99 South to Stockton and follow State Hwy 4 towards and beyond Farmington to the Park (through Angel's Camp). Driving time to the Park from Stockton is approx. 1 hour and 30 minutes. An alternate route is to take State Hwy 16 southeast to State Hwy 49 South to Angel's Camp, making a left turn on the far side of town on State Hwy 4 to the Park. Driving time from Angel's Camp is approximately 35 minutes.
Take US 395 to State Hwy 89 West to the terminus of State Hwy 4, up over Ebbett's Pass to the Park. The road is closed in Winter. It's very scenic, but very steep and windy. Motorhomes and cars with large trailers are not advised.